What will you be empowered to do?
Postdoctoral Fellow - Computational Biology, Parkinson’s Disease
Sunnyvale, California, United States
23andMe has amassed an incredible data resource for genetics and epidemiology research. With more than 12 million genotyped individuals and 10 billion phenotypic data points, we offer a true playground for discovery. Our postdoctoral fellowship program provides a fully funded 2 year opportunity to analyze and publish findings from cutting-edge explorations of this unique database. In the past, our postdocs have published on topics as diverse as historical genomes, Parkinson’s disease, and race/ethnicity in genetic research. We offer dedicated mentorship, opportunities to present at scientific meetings, and a chance to explore a career in the industry while still engaging in academic research and building a publication track record.
23andMe is seeking a postdoctoral candidate with experience in bioinformatics to join 23andMe’s postdoctoral program. You will work within our Parkinson’s disease (PD) research group and interact with other members of the research team in utilizing genetic and phenotype data to contribute to the advancement of Parkinson’s disease research, with a focus on better understanding who is at risk of developing PD and how fast their symptoms will progress.
Additionally, you will have access to the Fox Insight dataset via Fox DEN, generated through routine longitudinal assessments (health and medical questionnaires evaluated at regular cycles), one-time questionnaires on topics ranging from environmental exposure to the impact of COVID-19, and genetic data collection for more than 10,000 participants with PD. Fox Insight is The Michael J Fox Foundation’s online, longitudinal health study of people with and without Parkinson’s disease with over 50,000 participants at present. In addition to this main effort, there may be other opportunities with the 23andMe research team to contribute to Parkinson’s disease research.
With the world’s largest database of more than ten million genotyped customers, 23andMe is at the forefront of using human genetics to advance biomedical research and transform healthcare. Join our growing research team in translating genetic discoveries into insights into molecular biology of human traits and diseases. #LI-JNH1
Who We Are
Since 2006, 23andMe’s mission has been to help people access, understand, and benefit from the human genome. We are a group of passionate individuals pushing the boundaries of what’s possible to help turn genetic insight into better health and personal understanding.
What You'll Do
- Execute analyses in collaboration with our research group and a network of academic collaborators, using genotype and phenotype data from Fox DEN and from the 23andMe Research database
- With a focus on prodromal factors and the progression of the disease, these analyses may address a number of different needs including but not limited to:
- Integrate data sources to determine pheno-conversions to diagnosis
- Calculate disease severity scores considering neurological phenotypes and burden of motor and non-motor symptoms
- Better identification of “fast progressing” or “slow progressing” cohorts
- Identification of novel variables that correlate with PD risk and progression including polymorphic risk scores and environmental/behavioral factors
- Contribution to prodromal prediction tools and identifying high-risk individuals
- Open source tool development and assistance with curation activities to enhance the reusability and understandability of Fox DEN datasets
- Designing future large scale data collection initiatives
What You’ll Bring
- PhD in Genetics, Computational Biology, Data Analytics or related field
- Demonstrated fluency with tools and methods for analyzing genetic data
- Background in bioinformatics, biostatistics, and algorithm development
- Proficiency in Python and R
- Familiar with cloud computing services
- Experience in genetic association analyses and demonstrated interest in statistical genetics
- Excellent communication skills are essential as you will be expected to publish and present the results of your work.
23andMe, headquartered in Sunnyvale, CA, is a leading consumer genetics and research company. Founded in 2006, the company’s mission is to help people access, understand, and benefit from the human genome. 23andMe has pioneered direct access to genetic information as the only company with multiple FDA authorizations for genetic health risk reports. The company has created the world’s largest crowdsourced platform for genetic research, with 80 percent of its customers electing to participate. The platform also powers the 23andMe Therapeutics group, currently pursuing drug discovery programs rooted in human genetics across a spectrum of disease areas, including oncology, respiratory, and cardiovascular diseases, in addition to other therapeutic areas. More information is available at www.23andMe.com.
At 23andMe, we value a diverse, inclusive workforce and we provide equal employment opportunity for all applicants and employees. All qualified applicants for employment will be considered without regard to an individual’s race, color, sex, gender identity, gender expression, religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. If you are unable to submit your application because of incompatible assistive technology or a disability, please contact us at firstname.lastname@example.org. 23andMe will reasonably accommodate qualified individuals with disabilities to the extent required by applicable law.
Please note: 23andMe does not accept agency resumes and we are not responsible for any fees related to unsolicited resumes. Thank you.