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Proactive Health Management

Power Your GLP-1 Journey with Breakthrough Genetic Research

23andMeplus Total Health™
Sample Total Health reports
Sample Total Health reports
Proactive Health Management

Power Your GLP-1 Journey with Breakthrough Genetic Research

23andMeplus Total Health™
  • See how your DNA and other factors could impact your weight loss and likelihood of nausea on GLP-1 medications, based on genetic and non-genetic insights from our landmark Nature study.
  • Access 50+ cutting-edge polygenic risk score (PRS) reports to learn about your likelihood of developing a number of weight-related health conditions, including predispositions to a higher weight, type 2 diabetes, coronary artery disease, and nonalcoholic fatty liver disease (NAFLD).
  • Go deeper with next-generation sequencing (NGS) of the exome to identify rare variants linked to 50+ serious health conditions, including for cardiovascular disease, kidney disease, and metabolic disease.
  • Establish a clinical health baseline with biannual blood panels to track key biomarkers and metabolic progress over time, with results reviewed by an independent board-certified clinician.

FSA & HSA eligible

Beyond Trial and Error

GLP-1s: Why Your Genetics Matters

Starting a GLP-1 medication is a major commitment. While these drugs can be transformative, clinical data shows that individual experiences vary significantly. 23andMe’s research-backed report can help you and your doctor personalize your GLP-1 weight loss journey from day one.

Understand Your Potential Weight Loss

Understand Your Potential Weight Loss

Our researchers identified a specific variant in the GLP1R gene that can impact how much weight you may lose on GLP-1 medications. Understanding your genetic predisposition can help you set realistic expectations and personalize your weight loss strategy.

Manage Side Effects Proactively

Manage Side Effects Proactively

Nausea and vomiting are among the leading reasons patients stop GLP-1 therapy. By understanding how your genetics, including specific variants in the GLP1R and GIPR genes, and other factors impact your likelihood, you can work with your clinician to manage potential side effects.

Data-Backed Confidence

Data-Backed Confidence

Our new GLP-1 report is powered by a landmark study of over 27,000 participants, providing you with an interactive tool that combines DNA, age, and health history for unique insights into how you might respond to GLP-1s.

A Foundation for Long-Term Success

A Foundation for Long-Term Success

A weight-loss journey is about more than a single medication. Your Total Health membership includes clinical interpretations of 100+ high-impact genes associated with 55+ health conditions to help you manage your broader wellness. Use these genetic insights to understand your risk for hereditary diseases affecting your metabolic, kidney, and cardiovascular systems as you work toward and maintain your health goals.

Longevity: a new take on growing older.

Total Health is a longevity platform built with exome sequencing and blood biomarker analysis. Equipping you with the tools to age with health, productivity, and grace.

Analyzes genetics and blood for:

  • Heart Health
  • Brain & Nerve Health
  • Cancer
  • Kidney Health
  • Metabolic Health
  • Heart Health
  • Brain & Nerve Health
  • Cancer
  • Kidney Health
  • Metabolic Health
  • Pharmacogenetics
  • Liver Health
  • Thyroid Health
  • Blood & Immune Health
  • Eye & Ear Health
  • Pharmacogenetics
  • Liver Health
  • Thyroid Health
  • Blood & Immune Health
  • Eye & Ear Health
  • Digestive Health
  • Skin & Hair
  • Lung Health
  • Reproductive Health
  • Digestive Health
  • Skin & Hair
  • Lung Health
  • Reproductive Health
"Longevity isn't about living more years. It's about living more healthy years. And the key to doing that is within us."
Noura Abul-Husn, MD, PhD
Chief Medical Officer, 23andMe

Be the architect of your health.

With exome sequencing and biannual blood analysis, Total Health gives you the tools to build longevity and resilience in an evolving world.

Exome Sequencing

Looks closer, 200x closer.

Exome Sequencing
.Looks closer, 200x closer.

Exome sequencing is next level genetic screening that analyzes a portion of your total DNA, detecting 200x more disease-causing variants.‡ Total Health offers sequencing and interpretations of 100+ high impact genes associated with 55+ health conditions that, if detected early, may have effective preventive measures and interventions.

  • Includes conditions that increase your risk for arrhythmia, heart attacks, and aneurysms.

    Image Description: A sample result for Hereditary Cardiovascular Disease report; "No variants detected (of 44 genes tested).

  • Includes conditions that increase your risk for breast, ovarian, and colorectal cancer.

    Image Description: A sample result for Hereditary Cancer report; "No variants detected (of 33 genes tested).

  • Includes conditions like Parkinson's and Alzheimer's Disease.

    Image Description: A sample result for Hereditary Neurological Disease report; "A variant was detected in the APOE gene."

Hereditary Cardiovascular Disease

Includes conditions that increase your risk for arrhythmia, heart attacks, and aneurysms.

Biological Age

Change the way you age.

Biological Age refers to how your body is aging, and is determined by analyzing biomarkers that reflect the condition of major body systems and organs. Checked biannually so you can track it and take steps to potentially slow down or even reverse course.

Blood Testing
.Don't guess, test.

With ~70% of clinical decisions relying on lab data1, Total Health tests more frequently and looks at more things. Specifically, 55+ key blood biomarkers are analyzed biannually to provide a more comprehensive picture of overall health.

  • Thyroid disorders can have a big impact on your health, but are often undiagnosed. TSH is used to identify hypothyroidism (too little thyroid hormone) or hyperthyroidism (too much).

    Image Description: A sample result for Thyroid-stimulating hormone (TSH) report; "Your TSH levels are in the normal range."

  • Rarely tested, Lp(a) is the stickiest of the “bad” cholesterols and most likely to cause blockages in the arteries, increasing risk for cardiovascular disease.

    Image Description: A sample result for Lipoprotein(a) (Lp(a)) report; "Your Lp(a) levels are in the optimal range."

  • In addition to other cholesterol testing, ApoB is being recognized as a key part of providing a more accurate and complete picture of a person’s overall risk for cardiovascular disease.

    Image Description: A sample result for Apolipoprotein B (ApoB) report; "Your ApoB levels are in the moderate range."

  • HbA1c can help in diagnosing and monitoring prediabetes and diabetes. Most people are unaware they have prediabetes due to lack of symptoms so testing is the only way to uncover it.

    Image Description: A sample result for Hemoglobin A1c (HbA1c) report; "Your HbA1c levels are in the abnormal range."

Thyroid-stimulating hormone (TSH)

Thyroid disorders can have a big impact on your health, but are often undiagnosed. TSH is used to identify hypothyroidism (too little thyroid hormone) or hyperthyroidism (too much).

Your path to longevity starts now.

Exome sequencing paired with enhanced blood testing, guided by experts.

  • Biannual blood testing with advanced cardiometabolic biomarkers.
  • Monitor how your body is aging with Biological Age.
  • Includes 23andMe+ Premium.*
  • FSA/HSA eligible⬥
  • Not available to residents of HI, NJ, NY, RI and US territories.
Membership renews at peryr.

Not available to residents of HI, NJ, NY, RI and US territories.

Which service will you
start with today?

Remember, you can always upgrade without having to spit again.

FeatureAncestryHealth + Ancestry

Ancestry
Service

$149
Add to cart-ancestry

Health plus
Ancestry
Service

$269
Add to cart-healthImportant test info
Genetic health screening
-10+ conditions
Ancestry and Trait Reportsincludedincluded
DNA Relative Finder and Family Tree (Opt in)includedincluded
Health Predisposition reports*Learn about Considerations and Limitations for Health Predispositions Reports, Carrier Status Reports and Genetic Health Risks
not included10+
Carrier Status reports*Learn about Considerations and Limitations for Health Predispositions Reports, Carrier Status Reports and Genetic Health Risks
not includedincluded
Wellness reports
not included5+
Family Health History Tree
not includedincluded
Pharmacogenetics reports**Learn about Considerations and Limitations for Pharmacogenetics Reports
not includednot included
Enhanced ancestry features
not includednot included
Historical Matches
not includednot included
Breast, Prostate and Colorectal Cancer reports

all Powered by 23andMe Research		not includednot included
Health Tracks
not includednot included
Ongoing new reports
and features
not includednot included

Things you might be wondering:

To be eligible for 23andMe+ Total Health, you must be 18 years or older and live in the US — excluding HI, NJ, NY, RI and US territories (due to state and regional restrictions). You must not have received a blood transfusion in the last 30 days or a bone marrow transplant.
Because there are multiple steps involved with 23andMe+ Total Health, your reports will arrive over a period of time after you complete certain steps. You'll receive your genotyping results 4-6 weeks after registering your kit. You'll receive your exome sequencing reports 7-12 weeks after your genotyping reports.
All saliva samples are processed in Clinical Laboratory Improvement Amendments (CLIA) certified and College of American Pathologists (CAP) accredited labs.
Clinical services are provided by healthcare providers which includes board-certified physicians and nurse practitioners. All clinicians have unique knowledge and training in genetics-informed care.
Genotyping examines DNA variants at certain pre-identified positions in the genome. Sequencing is an advanced type of genetic testing which involves determining the exact sequence of a certain length of DNA. Exome sequencing looks at approximately 40 times more DNA bases than microarray genotyping chips.
Exome sequencing is a specialized genetic sequencing technique that focuses on decoding the exome of an individual's genome. The exome represents the protein-coding regions of genes, which make up only about 1-2% of the entire genome but contain the majority of genetic variants associated with disease risk.
The genes included in the 23andMe+ Total Health Exome Sequencing reports were carefully selected to provide high-impact genetic risk information. These include all of the genes considered "medically actionable" by the American College of Medical Genetics and Genomics (ACMG) along with other genes that can provide both clinical and personal benefit.
Our researchers identified specific genetic variants in the GLP1R and GIPR genes that are associated with weight loss and nausea on GLP-1 medications. By analyzing these variants alongside your health history, age, and BMI, our interactive report provides insights into how these factors could impact your weight loss and your likelihood of experiencing nausea and vomiting on GLP-1s.
The report and interactive tool are designed to provide insights for popular GLP-1 medications used for weight loss and type 2 diabetes management, including semaglutide (such as Ozempic® and Wegovy®) and tirzepatide (such as Mounjaro® and Zepbound®).
Yes. The findings used in this report are based on a landmark 23andMe study of over 27,000 participants, which was published in the scientific journal Nature. This research represents a significant breakthrough in understanding why some individuals experience more weight loss than others on GLP-1 medications, and why some people experience nausea while others don't. Among 23andMe research participants, weight loss can vary between 6% and 20% of starting body weight, and the chances of nausea or vomiting can range from 5% to 78%, depending on genetics and other factors. The report uses these insights to let you see how your genetics and other factors could impact your weight loss and likelihood of nausea on GLP-1 medications.
As part of your Total Health membership, clinicians are available to help you understand what your report may mean for you. We also encourage you to share your report with your own healthcare provider, as it can facilitate shared decision-making and help manage expectations for your treatment journey.

*The 23andMe PGS test includes pharmacogenetic reports that provide information about how genetics may affect response to certain medications. It does not provide medical advice, and does not determine whether a medication is appropriate for you. Talk with your healthcare provider before making any changes to your medications.

‡23andMe Exome Sequencing analyzes approximately 1.5% of the genome to detect more disease-causing variants than genotyping alone.

ΔExome Sequencing detects rare and common variants associated with genetic health conditions. Results are not diagnostic. Talk to a healthcare professional about your results.

23andMe+ Total Health is not available to residents of HI, NJ, NY, RI and US territories.

⬥FSA/HSA eligibility may vary. Check with your benefits provider.