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Clinical Grade

Exome Sequencing for Ultimate Longevity

23andMeplus Total Health™
Sample Total Health reports
Sample Total Health reports
Clinical Grade

Exome Sequencing for Ultimate Longevity

23andMeplus Total Health™
  • Detects 200x more disease-causing variants than standard genotyping, maximizing early detection.
  • Includes biannual blood testing (55+ blood biomarkers) and Biological Age tracker.
  • Get a personalized preventive care Health Action Plan and all the features in 23andMe+ Premium.
$499
$499

FSA & HSA eligible

Longevity: a new take on growing older.

Total Health is a longevity platform built with exome sequencing, blood biomarker analysis, and expert clinician oversight. Equipping you with the tools to age with health, productivity, and grace.

Analyzes genetics and blood for:

  • Heart Health
  • Brain & Nerve Health
  • Cancer
  • Kidney Health
  • Metabolic Health
  • Heart Health
  • Brain & Nerve Health
  • Cancer
  • Kidney Health
  • Metabolic Health
  • Pharmacogenetics
  • Liver Health
  • Thyroid Health
  • Blood & Immune Health
  • Eye & Ear Health
  • Pharmacogenetics
  • Liver Health
  • Thyroid Health
  • Blood & Immune Health
  • Eye & Ear Health
  • Digestive Health
  • Skin & Hair
  • Lung Health
  • Reproductive Health
  • Digestive Health
  • Skin & Hair
  • Lung Health
  • Reproductive Health
"Longevity isn't about living more years. It's about living more healthy years. And the key to doing that is within us."
Noura Abul-Husn, MD, PhD
VP of Genomic Health, 23andMe

Be the architect of your health.

With exome sequencing, biannual blood analysis, and 1:1 clinician guidance, Total Health gives you the tools to build longevity and resilience in an evolving world.

Exome Sequencing

Looks closer, 200x closer.

Exome Sequencing
.Looks closer, 200x closer.

Exome sequencing is next level genetic screening that analyzes a portion of your total DNA, detecting 200x more disease-causing variants.‡ Total Health offers clinician-ordered sequencing and clinical interpretations of 100+ high impact genes associated with 55+ health conditions that, if detected early, may have effective preventive measures and clinical interventions.

  • Includes conditions that increase your risk for arrhythmia, heart attacks, and aneurysms.

    Image Description: A sample result for Hereditary Cardiovascular Disease report; "No variants detected (of 44 genes tested).

  • Includes conditions that increase your risk for breast, ovarian, and colorectal cancer.

    Image Description: A sample result for Hereditary Cancer report; "No variants detected (of 33 genes tested).

  • Includes conditions like Parkinson's and Alzheimer's Disease.

    Image Description: A sample result for Hereditary Neurological Disease report; "A variant was detected in the APOE gene."

Hereditary Cardiovascular Disease

Includes conditions that increase your risk for arrhythmia, heart attacks, and aneurysms.

Biological Age

Change the way you age.

Biological Age refers to how your body is aging, and is determined by analyzing biomarkers that reflect the condition of major body systems and organs. Checked biannually so you can track it and take steps to potentially slow down or even reverse course.

Blood Testing
.Don't guess, test.

With ~70% of clinical decisions relying on lab data1, Total Health tests more frequently and looks at more things. Specifically, 55+ key blood biomarkers are analyzed biannually to provide a more comprehensive picture of overall health.

  • Thyroid disorders can have a big impact on your health, but are often undiagnosed. TSH is used to identify hypothyroidism (too little thyroid hormone) or hyperthyroidism (too much).

    Image Description: A sample result for Thyroid-stimulating hormone (TSH) report; "Your TSH levels are in the normal range."

  • Rarely tested, Lp(a) is the stickiest of the “bad” cholesterols and most likely to cause blockages in the arteries, increasing risk for cardiovascular disease.

    Image Description: A sample result for Lipoprotein(a) (Lp(a)) report; "Your Lp(a) levels are in the optimal range."

  • In addition to other cholesterol testing, ApoB is being recognized as a key part of providing a more accurate and complete picture of a person’s overall risk for cardiovascular disease.

    Image Description: A sample result for Apolipoprotein B (ApoB) report; "Your ApoB levels are in the moderate range."

  • HbA1c can help in diagnosing and monitoring prediabetes and diabetes. Most people are unaware they have prediabetes due to lack of symptoms so testing is the only way to uncover it.

    Image Description: A sample result for Hemoglobin A1c (HbA1c) report; "Your HbA1c levels are in the abnormal range."

Thyroid-stimulating hormone (TSH)

Thyroid disorders can have a big impact on your health, but are often undiagnosed. TSH is used to identify hypothyroidism (too little thyroid hormone) or hyperthyroidism (too much).

Clinician Oversight
.Your expert-planned action plan.

All of this sophisticated health data is only helpful if you know what to do with it. So you'll work with an expert clinician trained in genetics-informed preventive care and health action plans. You can reach them directly via unlimited messaging, as well as an in-depth consultation tailored to your results.

Unlimited Messaging

Have ongoing conversations with clinicians about your reports, your progress or questions about your health journey.

Your path to longevity starts now.

Exome sequencing paired with enhanced blood testing, guided by expert clinicians.

  • Identify disease risks with exome sequencing.Δ
  • Biannual blood testing with advanced cardiometabolic biomarkers.
  • Personalized health plan administered by specially trained clinicians, with unlimited messaging follow up.
  • Monitor how your body is aging with Biological Age.
  • Includes 23andMe+ Premium.*
  • FSA/HSA eligible⬥
$499
Membership renews at $199peryr.

Not available to residents of HI, NJ, NY, RI and US territories.

Things you might be wondering:

To be eligible for 23andMe+ Total Health, you must be 18 years or older and live in the US — excluding HI, NJ, NY, RI and US territories (due to state and regional restrictions). You must not have received a blood transfusion in the last 30 days or a bone marrow transplant.
Because there are multiple steps involved with 23andMe+ Total Health, your reports will arrive over a period of time after you complete certain steps. You'll receive your genotyping results 4-6 weeks after registering your kit. You'll receive your exome sequencing reports 7-12 weeks after your genotyping reports.
All saliva samples are processed in Clinical Laboratory Improvement Amendments (CLIA) certified and College of American Pathologists (CAP) accredited labs.
Clinical services are provided by healthcare providers which includes board-certified physicians and nurse practitioners. All clinicians have unique knowledge and training in genetics-informed care.
Genotyping examines DNA variants at certain pre-identified positions in the genome. Sequencing is an advanced type of genetic testing which involves determining the exact sequence of a certain length of DNA. Exome sequencing looks at approximately 40 times more DNA bases than microarray genotyping chips.
Exome sequencing is a specialized genetic sequencing technique that focuses on decoding the exome of an individual's genome. The exome represents the protein-coding regions of genes, which make up only about 1-2% of the entire genome but contain the majority of genetic variants associated with disease risk.
The genes included in the 23andMe+ Total Health Exome Sequencing reports were carefully selected to provide high-impact genetic risk information. These include all of the genes considered "medically actionable" by the American College of Medical Genetics and Genomics (ACMG) along with other genes that can provide both clinical and personal benefit.

*The 23andMe PGS test includes pharmacogenetic reports that provide information about how genetics may affect response to certain medications. It does not provide medical advice, and does not determine whether a medication is appropriate for you. Talk with your healthcare provider before making any changes to your medications.

‡23andMe Exome Sequencing analyzes approximately 1.5% of the genome to detect more disease-causing variants than genotyping alone.

ΔExome Sequencing detects rare and common variants associated with genetic health conditions. Results are not diagnostic. Talk to a healthcare professional about your results.

23andMe+ Total Health is not available to residents of HI, NJ, NY, RI and US territories.

⬥FSA/HSA eligibility may vary. Check with your benefits provider.