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Research & Science

Annotations Scientist

Sunnyvale, California, United States

With the world’s largest database of more than ten million genotyped customers, 23andMe is at the forefront of using human genetics to advance biomedical research and transform healthcare. Join our growing research team in translating genetic discoveries into insights into molecular biology of human traits and diseases.

As an Annotations Scientist at 23andMe, you will work closely with our Statistical Genetics and Computational Biology teams to source, curate, and implement databases for the analysis of genomic data in support of 23andMe’s drug target discovery and other research efforts. 

Who We Are

Since 2006, 23andMe’s mission has been to help people access, understand, and benefit from the human genome.  We are a group of passionate individuals pushing the boundaries of what’s possible to help turn genetic insight into better health and personal understanding.

What You'll Do

  • Identify, ingest and provide access to a comprehensive set of genomic and functional datasets.
  • Develop and implement a strategy for how to use and deploy genomics and functional annotations data at 23andMe, in support of interpretation of human genetic variation.
  • Develop tools and APIs for serving diverse genomics data types in a high-throughput and flexible manner.
  • Follow genetics, functional genomics, bioinformatics literature and attend appropriate conferences to maintain awareness of desirable and state-of-the-art annotations and methods.
  • Install, test, and deploy external tools to support curation, processing and high performance presentation of annotations to other researchers. 
  • Design and implement in-house tools and APIs when third-party tools are insufficient.
  • Develop, evaluate, and apply methods and test plans to assure data integrity and consistency.

What You'll Bring

  • Significant bioinformatics experience (at least three years) in a research setting, with a Ph.D. or M.S. in Bioinformatics, Computational Biology, Computer Science, Human Genetics, Molecular Biology or related field.
  • Expertise with tools and methods for predicting functional consequences of genetic variants (VEP, snpEff, etc.), and underlying models and data sources.
  • Proficiency with major bioinformatics resources (Ensembl suite, UCSC Genome Browser suite, TCGA, gnomAD/ExAC, GTEx, etc.) and in-depth understanding of at least one of these ecosystems.
  • Hands-on experience with relational databases (MySQL, Postgres, etc.) and fluency with at least one advanced data storage and retrieval technologies (such as Amazon Redshift, Hadoop, HDFS, etc.). 
  • Fluency in R/Python and occasionally other languages as needed for data processing and API development.
  • Experience with workflow development using shell scripting and standard GNU tools.
  • Experience working in cross-functional teams.  


  • Understanding of gene expression and gene regulation datasets, such as e/p/mQTLs, chromatin marks, etc.
  • Experience with cloud computing with AWS.
  • Ability to engineer and tune large scale databases for performant read and write access of large datasets.

About Us

23andMe, Inc. is the leading consumer genetics and research company. Our mission is to help people access, understand and benefit from the human genome. The company was named by MIT Technology Review to its “50 Smartest Companies, 2017” list, and named one of Fast Company’s “25 Brands That Matter Now, 2017”. 23andMe has over 5 million customers worldwide, with ~85 percent of customers consented to participate in research. 23andMe is located in Sunnyvale, CA. More information is available at

At 23andMe we value a diverse, inclusive workforce and we provide equal employment opportunity for all applicants and employees. All qualified applicants for employment will be considered without regard to an individual’s race, color, sex, gender identity, gender expression, religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. 23andMe will reasonably accommodate qualified individuals with disabilities to the extent required by applicable law.

Please note: 23andMe does not accept agency resumes and we are not responsible for any fees related to unsolicited resumes. Thank you.