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Therapeutics

Translational Scientist / Sr. Associate Translational Scientist

South San Francisco, California, United States

Who We Are

23andMe, the leading consumer genetics and research company, has accumulated a wealth of genotypic and phenotypic information from participants committed to improving human health through advances in genomics. Our Therapeutics team in South San Francisco leverages this data to discover and develop new treatments that can offer significant benefits for patients with serious, unmet medical needs.

This dedicated research and drug development group identifies novel targets using 23andMe's genetic database and performs preclinical research to advance programs towards clinical development. We currently have programs across several therapeutic areas, including but not limited to oncology, respiratory, and cardiovascular diseases. More information about our Therapeutics team is available at https://therapeutics.23andme.com/.

The use of biomarkers and diagnostics is central to understanding how our therapeutics work and identifying patients that benefit most from these therapies. Our Biomarker Translation function has a critical role in advancing our drug development programs and is responsible for conceptualizing and implementing biomarker strategies across our pipeline. This is a unique opportunity for an experienced, highly motivated scientist to join a newly growing team of translational biomarker scientists and technology subject matter experts and drive our biomarker and drug development effort in oncology. The ideal candidate will play a critical role in developing and executing biomarker strategies for lead programs by applying cutting edge, innovative technologies to analyze biological specimens, in support of pre-clinical and early stage clinical oncology programs at 23andMe. 

The candidate will be part of a matrix organization that serves preclinical and clinical stage programs, serve as the translational science lead on project teams and manage collaborations with various lab-based teams as well as external collaborators and contract research organizations. The candidate will be responsible for determining and implementing suitable biomarkers to evaluate disease heterogeneity, target engagement, mechanism of action and predictive correlates of efficacy to help guide the development of new therapeutics to treat human cancer.

What you'll do

  • Translational science lead on project teams accountable for biomarker strategies, results and timelines
  • Support novel therapeutic candidates before and after transition from discovery through all phases of clinical development
  • In close collaboration with discovery and development functions, leverage internal and external data, conceptualize a biomarker strategy for pipeline programs around disease heterogeneity and patient selection/stratification, target-engagement, mechanism of action and disease modification
  • Oversee the implementation of biomarker strategies for novel oncology molecules in early clinical trials using state of the art protein and molecular assays on tissue and liquid biopsies to support drug development efforts
  • Oversee external labs and research organizations for biosample management, assay development, tech transfer, validation and execution
  • Design focused experiments, author and implement protocols, execute biomarker studies, organize data, draft technical reports and regulatory documents

What you’ll bring

  • PhD with strong scientific background in immuno-oncology or immunology
  • 2-4 years of industry experience in the therapeutic development space, familiar with strategies of biomarker discovery and clinical translation
  • Solid experience with assay development principles (protein, nucleic acid, cellular)
  • Experience with assay development and validation remotely at CROs/specialty labs
  • Outstanding presentation and communication skills
  • Successful demonstration of initiative, teamwork, collaboration and technical expertise as an independent and creative scientist

Strongly Preferred

  • Documented ability to establish and execute clinical biomarker studies
  • Management of external collaborations and outsourcing through contract research organizations
  • Previous involvement in clinical diagnostic assay development for pharmacodynamic monitoring as well as patient selection implementation and/or familiarity with regulatory aspects of CDx development
  • Large dataset analysis
  • Poise and professionalism with strong communication and influencing skills in a dynamic environment

Note: Job title will be commensurate with experience and academic credentials.

About Us

23andMe, Inc. is the leading consumer genetics and research company. Founded in 2006, the mission of the company is to help people access, understand, and benefit from the human genome. The company was named by Glassdoor as one of the Best Places to Work in 2019, MIT Technology Review to its “50 Smartest Companies, 2017” list, and named one of Fast Company’s “25 Brands That Matter Now, 2017”. 23andMe has millions of customers worldwide, with more than 80 percent of customers consented to participate in research. More information is available at www.23andMe.com.

At 23andMe, we value a diverse, inclusive workforce and we provide equal employment opportunity for all applicants and employees. All qualified applicants for employment will be considered without regard to an individual’s race, color, sex, gender identity, gender expression, religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws.  If you are unable to submit your application because of incompatible assistive technology or a disability, please contact us at accomodations-ext@23andme.com. 23andMe will reasonably accommodate qualified individuals with disabilities to the extent required by applicable law.

Please note: 23andMe does not accept agency resumes and we are not responsible for any fees related to unsolicited resumes. Thank you.

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