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TTR-Related Hereditary Amyloidosis

What is TTR-Related Hereditary Amyloidosis?

TTR-related hereditary amyloidosis is a genetic condition caused by the buildup of a protein called transthyretin (TTR) in the body's tissues and organs. This protein buildup, called amyloidosis, can damage the nerves, the heart, and other parts of the body.

Is TTR-Related Hereditary Amyloidosis Genetic?

Yes,TTR-related hereditary amyloidosis is genetic. It is caused by genetic variants (differences) in the TTR gene. However, TTR-related hereditary amyloidosis is not the only cause of amyloidosis. There are other forms of hereditary amyloidosis that are caused by genetic variants in other genes. In addition, some people develop TTR-related amyloidosis without a genetic variant.

How TTR-Related Hereditary Amyloidosis Develops

The TTR gene contains instructions for making a protein called transthyretin. Certain variants in the TTR gene make the protein less stable, which can cause it to fold incorrectly and clump together into abnormal structures called amyloid fibrils. These amyloid fibrils can then build up in the body's tissues and organs.

Typical Signs and Symptoms

The symptoms depend on how much and where the build-up of protein occurs. The most common places of protein build-up are in the nerves and in the heart. Build-up of protein in the nerves can result in peripheral neuropathy and autonomic neuropathy (types of nerve damage). Symptoms of peripheral neuropathy can include carpal tunnel syndrome, as well as tingling, numbness, or burning in the hands, legs, or feet. Symptoms of autonomic neuropathy can include constipation, diarrhea, sexual dysfunction, and dizziness. Build-up of protein in the heart can lead to cardiomyopathy (heart damage), which can lead to heart failure.

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23andMe can tell you if you may have an increased risk of developing TTR-related hereditary amyloidosis based on your genetics. The 23andMe Hereditary Amyloidosis (TTR-Related) Genetic Health Risk report* looks for three genetic variants in the TTR gene linked to hereditary amyloidosis. You can get the report and more with the 23andMe Health + Ancestry Service.

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