23andMe+
Total Healthtrademark

23 chromosome pairs. 55 blood biomarkers. 200x more answers. Total Health, the sum total of living your healthiest life.

Join us
Familial medullary thyroid cancer
Multiple endocrine neoplasia type 2a
Multiple endocrine neoplasia type 2b
Peutz-Jeghers syndrome
Li-Fraumeni syndrome
Tuberous sclerosis complex
Von Hippel-Lindau syndrome
Wilms tumor
MUTYH-associated polyposis
Lynch syndrome
Pompe disease
Autosomal dominant polycystic kidney disease
Alzheimer's disease
Hereditary thrombophilia
Hereditary hemochromatosis
Leber congenital amaurosis
Retinitis pigmentosa
Alpha-1 antitrypsin deficiency
Thyroid-stimulating hormone
White Blood Cell Count
Red Blood Cell Count
Familial thoracic aortic aneurysm and dissection
Triglycerides
Familial hypertrophic cardiomyopathy
Blood Glucose
Parkinson's disease
Blood Urea Nitrogen
Creatinine
APOL1-related chronic kidney disease
Hereditary breast cancer
Lipoprotein (a)
Apolipoprotein B
Hemoglobin A1c
G6PD deficiency
Familial hypercholesterolemia
Brugada syndrome
Loeys-Dietz syndrome
Type III hyperlipoproteinemia
Myofibrillar myopathy
Long QT syndrome
Ehlers-Danlos syndrome, vascular type
Marfan syndrome
Familial medullary thyroid cancer
Multiple endocrine neoplasia type 2a
Multiple endocrine neoplasia type 2b
Peutz-Jeghers syndrome
Li-Fraumeni syndrome
Tuberous sclerosis complex
Von Hippel-Lindau syndrome
Wilms tumor

Longevity: a new take
on
growing older.

Total Health is a longevity platform built with exome sequencing, blood biomarker analysis, and expert clinician oversight. Equipping you with the tools to age with health, productivity, and grace.

Analyzes genetics and blood for:

  • Heart Health
  • Brain & Nerve Health
  • Cancer
  • Kidney Health
  • Metabolic Health
  • Heart Health
  • Brain & Nerve Health
  • Cancer
  • Kidney Health
  • Metabolic Health
  • Pharmacogenetics
  • Liver Health
  • Thyroid Health
  • Blood & Immune Health
  • Eye & Ear Health
  • Pharmacogenetics
  • Liver Health
  • Thyroid Health
  • Blood & Immune Health
  • Eye & Ear Health
  • Digestive Health
  • Skin & Hair
  • Lung Health
  • Reproductive Health
  • Digestive Health
  • Skin & Hair
  • Lung Health
  • Reproductive Health
Longevity isn’t about living more years. It’s about living more healthy years. And the key to doing that is within us.
Noura Abul-Husn, MD, PhD
VP of Genomic Health, 23andMe

Be the architect of your health.

With exome sequencing, biannual blood analysis, and 1:1 clinician guidance, Total Health gives you the tools to build longevity and resilience in an evolving world.

Biological Age

Change the
way you age.

Biological Age refers to how your body is aging, and is determined by analyzing biomarkers that reflect the condition of major body systems and organs. Checked biannually so you can track it and take steps to potentially slow down or even reverse course.

Your path to longevity starts now.

Exome sequencing paired with enhanced blood testing, guided by expert clinicians.

  • Identify disease risks with exome sequencing.Δ
  • Biannual blood testing with advanced cardiometabolic biomarkers.
  • Personalized health plan administered by specially trained clinicians, with unlimited messaging follow up.
  • Monitor how your body is aging with Biological Age.
  • Includes 23andMe+ Premium. Important test info.*
  • FSA/HSA eligible
  • Not available to residents of HI, NJ, NY, RI and US territories.
$999 First
Year
Membership renews at $499peryr.
Add to cart

Not available to residents of HI, NJ, NY, RI and US territories.

Things you might be wondering:

To be eligible for 23andMeplus Total Health, you must be 18 years or older and live in the US — excluding HI, NJ, NY, RI and US territories (due to state and regional restrictions). You must not have received a blood transfusion in the last 30 days or a bone marrow transplant.

Because there are multiple steps involved with 23andMeplus Total Health, your reports will arrive over a period of time after you complete certain steps. The estimated timeline is as follows:

  • You’ll receive 190+ genotyping reports 4-6 weeks after registering your kit, spitting and shipping your sample.
  • You’ll receive your exome sequencing reports 7-12 weeks after you receive your genotyping reports.
  • For each of the two blood tests, you’ll receive your analysis of 55+ biomarkers 3-5 business days after completing your blood draw.
  • You’ll have unlimited messaging with clinicians after receiving your PGS results and the opportunity to schedule your virtual consultation once exome results are returned.

All saliva samples are processed in Clinical Laboratory Improvement Amendments (CLIA) certified and College of American Pathologists (CAP) accredited labs.

Clinical services are provided by healthcare providers which includes board-certified physicians and nurse practitioners. All clinicians have unique knowledge and training in genetics-informed care.

Genotyping examines DNA variants at certain pre-identified positions in the genome. The specific variants we look at provide coverage of common known variations across the entire genome. Many variants can be accurately and efficiently examined at once using genotyping chips, also known as microarrays. This is the technology used to power the 190+ genotyping reports that you will receive.

Sequencing is an advanced type of genetic testing which involves determining the exact sequence of a certain length of DNA - a short piece, the whole genome, or parts of the genome such as the exome. It can be used to examine known variants, as well as identify variants that are unknown, providing you with a more complete picture of your genetic predispositions for certain health conditions. Exome sequencing looks at approximately40 times more DNA bases than microarray genotyping chips.

Exome sequencing is a specialized genetic sequencing technique that focuses on decoding the exome of an individual's genome. The exome represents the protein-coding regions of genes, which make up only about 1-2% of the entire genome but contain the majority of genetic variants associated with disease risk. By selectively sequencing these regions, exome sequencing provides valuable insights into an individual's genetic makeup, identifying variations that may be linked to specific genetic disorders or conditions. This technique is particularly useful for diagnosing rare genetic diseases and conducting research into the genetic basis of various medical conditions.

The 100+ genes included in the 23andMeplus Total Health Exome Sequencing reports were carefully selected to provide high-impact genetic risk information for 55+ conditions. These include all of the genes considered “medically actionable” by the American College of Medical Genetics and Genomics (ACMG) along with other genes that can provide both clinical and personal benefit. Overall, the genes selected can inform you about conditions that are often underdiagnosed. But, if detected early, there are many effective preventive measures and clinical interventions. See a full list of the genes and conditions .